Several years ago we became fascinated with the potential of adipose stem cells for both cosmetic and medical purposes. However, we soon discovered that nothing in the written FDA guidelines specifically addressed the use of autologous adipose stem cells. Thus began our journey for an answer. In June 2009, we sent a letter to the FDA asking for a position statement on adipose stem cells. Our request focused specifically on autologous, freshly isolated, adipose stem cells for use in reconstruction. These stem cells are from your own fat, for your own usage, and not culture expanded in a lab.
There have been several comments recently on one of my previous blog posts about tummy tuck swelling. While swelling is a definite concern, it’s only one of the possible complications following abdominoplasty. Other complications can include infection, wound separation, and fluid collections. Be sure to discuss these things with your plastic surgeon prior to your surgery. >> Continue reading Tummy Tuck Complications - Infection, Wound Separation, Seroma, Hematoma
Nearly everyone has heard of Groupon, the coupon site for daily deals. If you are on the receiving end as a consumer, it can be a great way to get some great deals. For over a year we have been seeing other plastic surgeons and dermatologists sell Botox® at huge discounts. Not wanting to be outdone by our competitors, we decided to explore our options for selling facial injectables such as Botox, Restylane, Juvederm and Sculptra via Groupon. Find out why we won’t be offering Botox discounts via Groupon. >> Continue reading Groupon Daily Deals for Botox - Violation of State Regulations?
Unless you are a science major, understanding the topic of stem cells can be daunting. The mainstream media has provided some good articles on the topic of Stem Cells, but there is a lot of misleading information out there.
President Obama ordered federal agencies, such as the FDA, to search their books and strike any overburdensome regulations. In June, the FDA quietly posted a request for comments to any existing regulations that are burdensome or outdated by technology. We passed the link on to Professor Mary Chirba who then submitted comments to the FDA regarding autologous stem cell therapies. She has graciously given us permission to post her comments here on our blog. >> Continue reading FDA Stem Cell Regulation and the English Language: switched at birth?
Fat grafting, also known as fat transfers or fat injections, is a plastic surgery procedure which removes fat from unwanted areas of your body, carefully processes the fat, and then reinjects your own adipose fat tissue where more volume is desired. Fat injections can help rejuvenate your face, your buttocks, your hands, or your breasts. Fat injections are also being used in breast reconstruction surgery. Fat grafting will restore volume to the breast and can be performed with or without an implant.
We attended Robin Young’s 6th annual Stem Cell Summit which was held this year on March 1st in New York City. Also in attendance were scores of public and private stem cell companies. Presentations included 21 adult stem cell companies, 3 embryonic companies, 7 device/instrumentation companies, and a panel of medical experts discussing Spinal Cord Injury. Each company gave a 10 to 15 minute presentation but we most enjoyed Dr. Arnold Caplan’s keynote address. Not only is he well known in academic circles, but he is no stranger to the biotech financial community, as he was the founder of Osiris Therapeutics (Nasdaq: OSIR), a publicly traded cell therapy company. Here are some highlights we took away from Caplan’s keynote speech entitled, The State of MSC’s in 2011. If you are interested in stem cells from adipose tissue, you don’t want to miss this! >> Continue reading Stem Cell Summit: Adipose Tissue has more Stem Cells than Bone Marrow
A reader of our blog posed a very interesting question having to do with stem cell activation. Briefly put,
“why do you need to inject stem cells into an area if the normal tissues in that area already have some stem cells present?”–Charles
To understand why, we will talk about two concepts with adipose derived stem cells: the stem cell niche, and stem cell activation . Adipose stem cells are stem cells that are derived from your own fat tissue.
The Stem Cell Niche
Stem cells usually exist in a low grade resting state in a controlled environment called a niche. The niche contains mesenchymal stem cells, also known as MSCs. The mesenchymal stem cell niche is usually located in the blood vessel wall itself.
The status quo for a niche is not full blown stem cell activity, but a level of activity finely attuned to its surroundings. These cells like to keep a stable environment (on the vessels) within the niche. They will only respond in a very specific way, to certain kinds of stimuli.
In a chronic disease state such as scar tissue or aged skin, the stem cells present in that tissue are responding in many small and measured ways to whatever is happening in the tissue. Stem Cells are trying to maintain balanced conditions, this is called homeostasis. There are no big changes, just a low-grade adaptation to aging or scar process. This is why the stem cells in the local tissue are not doing what you would like them to do. To get a stem cell to do what you want it to do, something else needs to happen. It needs to get activated. >> Continue reading Stem Cell Niches, Stem Cell Activation, and Superman
Taking the pulse at the various Stem Cell conferences around the country in 2010, we found that more clinical researchers are gravitating to adipose tissue as a source of stem cells. Bone marrow has historically been the default source of adult stem cells for researchers. Likewise, the volume of peer reviewed publications and research papers attesting to fat as an abundant source of stem cells has seen a tremendous increase in the past year.
New evidence points to an improvement in vascularity and blood flow when stem cells are more concentrated in the fat to be transplanted. For therapeutic approaches, reproducible protocols of adipose-derived stem cells isolation and a large amount of cells are necessary, in order to respond to the increasing demand. Therefore, to practically understand what happens when adipose tissue is manipulated in the operating room, we studied the most common methods of fat processing employed by most plastic surgeons, in order to see which method yields the highest quantity of stem cells. >> Continue reading Centrifugation of Fat Tissue Yields More Stem Cells than Originally Thought
Looking at your breasts the way a doctor does can be an emotional event full of new information which may be hard to process, but it is essential that you and your doctor are ‘on the same page’ regarding the type of implant and surgical approach that will be used.
Highlights from the 2010 ASPS Plastic Surgery Hot Topics Panel
We recently attended the annual ASPS National Plastic Surgery Meeting in Toronto. We particularly enjoyed the ‘Hot Topics’ panel session and have written an analysis of the notable presentations on Adipose Stem Cells by Dr. Robert Singer and Dr. Peter Rubin. >> Continue reading Plastic Surgery Hot Topics Session - Adipose Stem Cells
A recent study published by a team from University of Pittsburgh Medical School is encouraging for researchers, clinicians, and medical device makers who are developing adipose stem cell treatments for breast reconstruction. Learn about the history of fat grafting and the safety conclusions of the Pittsburgh study. >> Continue reading Stem Cell Enhanced Fat Grafting for Breast Reconstruction
Dr. Rodriguez has performed thousands of Cosmetic and Reconstructive surgeries during his 25+ year career. Specializing in multiple procedure makeovers, he is a member of the ASPS and a highly sought after surgeon in the Baltimore/Washington, DC area with 5 star patient reviews from many top medical review sites.
I absolutely LOVE Dr. Rodriquez and his staff. Everyone is very helpful and considerate. Dr. Rodriquez goes above and beyond to please his patients and provides the best results possible!
- Brazilian Butt Lift patient
Ricardo L RodriguezMD, LLC
1300 Bellona Avenue, Suite CLutherville-Timonium,