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CosmeticSurg Blog

Dr. Rodriguez discusses Plastic Surgery, Medicine, and Stem Cell Research

Adipose Stem Cell Clinical Trial Update- August 2012 (part 4)

It’s been over two months since I updated my database of  Adipose Stem Cell Clinical Trials.  I am tracking registered Clinical Trials in the ClinicalTrials.gov database. A lot has happened in only two months!  Since June 1, eight new Clinical Trials have been registered or updated to disclose starting dates in the ClinicalTrials.gov database . This brings the all time total of Adipose Stem Cell Clinical Trials to 62.

Adipose Stem Cells (ASC’s) are a type of Adult Stem Cell and are derived from fat tissue.  The common method of extraction to obtain Adipose Stem Cells involves liposuction and then isolation of the stem cells by processing the fat with enzymes. The freshly isolated stem cells can be obtained in the same operative session and are referred to as Stromal Vascular Fraction (SVF).  Adipose Stem Cells can also be culture expanded in a GMP lab to yield even higher numbers of cells. However, culture expansion takes days or weeks in a lab.

CONDITIONS UNDER STUDY

Adipose Stem Cells are currently being used in Clinical Trials to treat and cure a wide range of diseases. My original project summary detailed the conditions under study.  Conditions include Arthritis, Autism, Crohn’s, Fistula, Kidney, MS, Pulmonary, Diabetes, Cardiac, Neuro, Orthopedic, Reconstructive, and others.

Since June,  the conditions with the highest number of new registered Clinical Trials using Adipose Stem Cells included the Brain and Orthopedic conditions.  Other conditions in the newly registered Clinical Trial studies include Fistula, Heart, Neuro, and Pain.

All of the new trials are using autologous Adipose Stem Cells, except for the trials studying Brain conditions. Clinical Trials to study Brain conditions are using both autologous and allogeneic Adipose Stem Cells (ASC’s). In Taiwan researchers are studying Severe Brain Injury with autologous ASC’s, but using allogeneic ASC’s to treat Cerebellar Ataxia. Autologous stem cells are your own stem cells, and allogeneic stem cells are from another person.
Adipose Stem Cell Clinical Trials July/August 2012

WAYS PATIENTS RECEIVE ADIPOSE STEM CELLS

The ways that these Adipose Stem Cells are being delivered to patients include direct injection, intracoronary, and IV infusion. Quite interesting was that both Brain Trials are using high dosages of Adipose Stem Cells by IV infusion into the bloodstream. The idea is that these Stem Cells or their cytokines will home to the place of injury–the brain. Many researchers believe that Adipose Stem Cells do cross the Blood/Brain barrier.

SPAIN AND KOREA LEAD ASC SECTOR

As I outlined in a previous post, Spain is the all time leader of Adipose Stem Cell Clinical Trials (at ClinicalTrials.gov) with 18 total Trials. However, during the past two months,  Korea is catching up. Of the 8 newly recorded Clinical Trials, Korea registered a total of 4 trials, with Taiwan, Netherlands, and the USA registering the remaining four trials. Korea now has an all time total of 16 Adipose Stem Cell Clinical Trials.

by Leeza Rodriguez
CosmeticSurg Staff Writer

Leeza Rodriguez on Google +

If you are just tuning in for the first time, please read the entire Adipose Stem Cell Clinical Trial collection

© Cosmeticsurg.net (permission to copy chart within article ONLY if proper attribution is given, including a link to the original source URL)

Posted in Adipose Clinical Trials Fat Stem Cells

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3 Comments

  • wrote
    September 12, 2013 at 3:48 pm

    James:
    This is a new field and it is hard to find valuable data.
    I can only report on the work I do.
    At the present time I would only go to places that are conducting studies, because they have to be very rigorous about their methods.

  • wrote
    February 4, 2013 at 5:48 pm

    A lot of clinics doing the autologous adipose stemcell infusions or injections the same day. Any reliable ones in southern Calif or Arizona? Also are the anecdotes from people who have had this generally positive? it is hard to find any solid data.

  • wrote
    August 29, 2012 at 6:27 pm

    Thank you for these clinical trial updates. The work you are doing is amazing and will surely help us to further understand how we can used adipose stem cells in cosmetic surgery and perhaps even disease prevention or treatment in the future. I’ll be keeping an eye on your blog!

    Best Regards,
    Dr. Asare

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