• Archives

  • Subscribe

    Enter your email address:


    Delivered by FeedBurner
  • Our Visitors

    Visitor Map

CosmeticSurg Blog

Dr. Rodriguez discusses Plastic Surgery, Medicine, and Stem Cell Research

Adipose Stem Cell Clinical Trial Update June 2012

Anyone who reads this blog knows that we are passionate about the future of adipose stem cells. Adipose stem cells are stem cells that are derived from your own fat. Many people know about their ability to enhance fat grafts for breast reconstruction, but we hear very little in the general media about their ability to cure and treat many diseases. Unless you are a biotech investor hanging out in Cytori message boards, you may not know that many Phase I clinical trials with adipose stem cells have even been completed.

To better understand the range of diseases being treated, I made a spreadsheet of all the clinical trials using adipose stem cells. This idea is an extension of Dr. Alexey Bersenev’s tracking of Cell Therapy Trials at his Hematopoiesis Blog. Dr. Bersenev is tracking *all* Cell Therapy trials registered since Jan 2011. Since my interest is primarily adipose stem cells, my spreadsheet tracks all clinical trials using only adipose stem cells since 2004. My thanks to Dr. Bersenev for setting up a great framework to build upon!

Each week I plan to publish data or charts from my spreadsheet. The charts below represent a few data sets from the spreadsheet. I have read and collected info about each clinical trial to include sponsor, trial status, country, donor source, disease indication, cell expansion, stem cell dosages, etc. so this could get very interesting! Not to be missed next week is the ‘sponsor’ who has 10 clinical trials registered for several different disease indications. It is amazing what one finds buried in those documents.

Adipose Stem Cell Clinical Trials as of June 2012

adipose stem cell clinical trial update chart

There are not only scores of adipose stem cell clinical trials that are ongoing, but many have already been completed. By my count, a total of 54 clinical trials using adipose stem cells have been registered with the clinicaltrials.gov database. This database houses all of the trials registered by the FDA and the NIH. A total of 13 trials have been completed, and 27 are actively recruiting. The remaining trials have various statuses. Keep in mind that this does not include trials registered at the many other country specific databases. Likewise, it does not include the pre-clinical studies that take place prior to registering for a clinical trial.

The endpoints of many of these completed trials is the determination of ‘safety’ and ‘efficacy’. To make a long story short, all completed studies determined that therapies using adipose stem cells are safe.

Disease Indications for Adipose Stem Cell Trials

While breast reconstruction using adipose stem cells has gotten a lot of media attention because of Suzanne Somers’ experience, there are adipose stem cell clinical trials ongoing for many diseases. These include arthritis, autism, cardio, crohn’s, diabetes, fistula, immune, kidney, liver, multiple sclerosis, neuro, orthopedic, pulmonary, vascular and wound care. Below is a summary of trial numbers for each indication. A LOT is going on!

stem cell clinical trial disease indications graph

 

Adipose Stem Cell Clinical Trials: SVF vs. Culture Expansion

Clinical trials use either Stromal Vascular Fraction (SVF), or the cells are Culture Expanded. Trials that use SVF isolate the stem cells from the fat removed during a liposuction procedure. Doctors then use those stem cells in the same operative session as the therapeutic treatment. The process of isolating the stem cells takes about an hour. It can be done manually or with special devices like the Cytori Celution machine. When trials use culture expanded stem cells, this means the cells can not be used on the same day as the therapeutic procedure. Cell culture expansion takes place in a GMP lab and can not be done in one day. Culture expansion of cells can take several weeks depending on the number of cells needed. Trials that use culture expanded cells need high cell counts, as well as certain phenotype populations of stem cells.

The chart below indicates that both methods of cell preparation are being used in trials. As time goes on, I will continue to slice and dice this info according to disease indication.

Adipose CTs - SVF vs Culture Expanded pie chart

Ongoing Data Collection Project

If you are interested in this project let me know! Consider signing up for our blog feed so that you can continue to receive updates either by email or with your favorite feedreader. I welcome your feedback and clarity as I plan to expand my database to include the WHO, and country-specific databases. Another big thanks goes to my Googley son who works in Mountain View HQ. I would not have been able to figure out all the magical charting features of Google spreadsheets without him!


by Leeza Rodriguez
CosmeticSurg Staff Writer
Google


Update: If you are just tuning in for the first time, please find follow up Adipose Stem Cell Clinical Trial Posts here:

© Cosmeticsurg.net (permission to copy article or part of article provided this notice is included and proper attribution is given, including a link to the original source URL)

Posted in Adipose Clinical Trials Fat Stem Cells

Post a Comment

Your email is never shared. Required fields are marked *


*
*




5 Comments

  • wrote
    August 31, 2012 at 11:44 am

    These are some good charts. I have to say this is very interesting to me.

  • wrote
    July 1, 2012 at 7:42 pm

    hi Richard, Can you share any details with us-? Are you part of a clinical trial? Were your injections intravenous? autologous? tissue source? We wish you all the best. Please keep us posted on your progress.

  • wrote
    July 1, 2012 at 7:32 pm

    I have SPMS with 6 adipose treatments so I have an idea how effective it may be.

  • wrote
    June 5, 2012 at 10:55 pm

    I very much appreciate your efforts

  • wrote
    June 4, 2012 at 8:49 pm

    excellent chart whoich clearly indicates the potential short and long term. also is encouraging as an investor. please keep me posted I appreciate your excellent work.

One Trackback

  1. [...] clinical trials analysis Leeza Rodriguez has joined our cell therapy clinical trials network. She analyzed and posted adipose stem cell clinical trials, registered in ClinicalTrials.gov. Each week I plan to publish [...]